Understanding Chronic Pain Treatments: The Basics
Chronic pain treatments encompass medications (NSAIDs, antidepressants, anticonvulsants), physical therapies (exercise, PT), interventional procedures (injections, nerve blocks), psychological approaches (CBT), and complementary therapies (acupuncture, massage). Most effective treatment plans combine multiple approaches custom to your specific pain condition.
| Treatment Type | Examples | Best For | Average Effectiveness |
|---|---|---|---|
| Medications | NSAIDs, anticonvulsants | Most pain types | Reduces pain by ~30% |
| Physical Therapy | Exercise, stretching | Musculoskeletal pain | Improves function |
| Interventional | Injections, nerve blocks | Specific nerve/joint pain | Months of relief |
| Psychological | CBT, mindfulness | All chronic pain | Improves coping |
| Complementary | Acupuncture, massage | Various pain types | Used by 27-60% of patients |
Living with chronic pain can feel like being trapped in a maze with no exit. About 25% of adults in the United States experience chronic pain – pain that persists for more than three months and interferes with daily activities.
Chronic pain is complex. It’s not just about physical sensations – it’s about how your nervous system processes pain signals, how your mind responds, and how your life circumstances affect your experience of pain. That’s why finding effective treatment often requires trying multiple approaches.
I’m Dr. Zach Cohen, a Board Certified specialist in Anesthesiology and Chronic Pain Medicine who has helped thousands of patients steer chronic pain treatments. My experience has taught me that while complete pain elimination is rarely possible, significant improvement in quality of life is achievable for most patients with the right combination of therapies.

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Chronic vs. Acute Pain 101
Have you ever wondered why some pain goes away quickly while other pain seems to stick around forever? The difference matters when it comes to finding relief.
Acute pain is your body’s alarm system – it warns you of injury or illness and typically fades as healing occurs. Chronic pain persists beyond the normal healing period (usually defined as more than three months) and can become its own condition.
Types of Chronic Pain
Your chronic pain likely falls into one of these categories:
Nociceptive pain stems from tissue damage or inflammation – like the aching in your knee from arthritis or the throbbing in your back after moving furniture. This type typically responds well to traditional chronic pain treatments like anti-inflammatories.
Neuropathic pain feels different. When the nervous system itself is damaged, you might experience shocking, burning, or tingling sensations. If you’ve ever had shingles or diabetic nerve pain, you know exactly how this feels. These sensations require different chronic pain treatments than nociceptive pain.
Nociplastic pain is perhaps the most frustrating type. Your body feels real pain, but doctors can’t find a clear physical cause. Conditions like fibromyalgia fall here. Your nervous system essentially amplifies pain signals even though there’s no ongoing tissue damage.
Central Sensitization: When Your Pain System Gets Stuck
Imagine if the volume knob on your pain signals got turned up and then broke in that position. That’s central sensitization in a nutshell.
“Think of it like a car alarm that goes off when someone merely walks past your car,” explains Dr. Cohen. “Your nervous system is responding to stimuli that wouldn’t normally be painful.”
Diagnosing Chronic Pain
Getting to the bottom of chronic pain isn’t always straightforward. Your doctor will likely take a detailed medical history, perform a physical examination, use validated pain scales, and order diagnostic tests when appropriate.

Understanding the neurobiology of pain is crucial for effective treatment. Pain isn’t just a sensation; it’s a complex experience influenced by physical, emotional, and cognitive factors. This is why the most effective chronic pain treatments address multiple aspects of your pain experience.
For a deeper scientific understanding of pain mechanisms, the International Association for the Study of Pain offers comprehensive resources.
Mapping the Most Common Chronic Pain Treatments
When I talk to my patients at California Pain Consultants, I describe our approach as a treatment pyramid – a roadmap that helps us steer the complex landscape of pain management together, starting with the safest, least invasive options before considering more intensive treatments.
The Treatment Pyramid
Think of your pain management journey as climbing a pyramid, where we start at the wide base with foundational approaches before moving upward only as needed. At the foundation, we focus on lifestyle changes and self-management strategies. Then we progress to physical therapies and non-opioid medications before considering minimally invasive procedures. Only when these approaches don’t provide adequate relief do we consider more advanced interventions.
Multimodal Approach: The Gold Standard
Combining treatments works better than relying on just one approach. Most chronic pain treatments can reduce pain by about 30% on average. When we layer several 30% improvements together, the results can be life-changing.
“I used to tell my patients to expect a magic bullet,” shares Dr. Cohen. “Now I know better. It’s more like assembling a pain relief orchestra—each instrument contributes something unique, and together they create something much more powerful.”
Shared Goals of Chronic Pain Treatment
When we develop your treatment plan, we’re aiming for more than just reducing your pain score. We want to help you move more freely, sleep better, enjoy your favorite activities again, and address related issues like depression or anxiety that often accompany chronic pain.

Common Chronic Pain Treatments by Condition
Your pain is unique, and certain treatments tend to work better for specific conditions. For low back pain, we often start with core strengthening exercises and physical therapy, perhaps adding anti-inflammatory medications or interventional procedures when needed. Many patients have found significant relief through these approaches, which you can explore further in our back-pain services.
If you’re dealing with neuropathic pain, medications like gabapentin or duloxetine often help, and advanced options like spinal cord stimulation can be transformative for the right candidates.
For fibromyalgia patients, I’ve seen remarkable improvements with regular gentle exercise, better sleep habits, and stress reduction techniques, often supported by specific medications and cognitive behavioral therapy.
And if osteoarthritis is your challenge, we typically focus on weight management, physical therapy, and appropriate use of medications and injections to keep you moving comfortably.
Ranking Chronic Pain Treatments: What Works?
Exercise has strong evidence behind it for conditions like low back pain and fibromyalgia. Cognitive behavioral therapy also has robust research supporting its effectiveness across many pain conditions.
For medication options, NSAIDs work well for inflammatory pain, while anticonvulsants often help with nerve pain. Procedures like radiofrequency ablation have strong evidence for certain types of joint pain.
Treatments with moderate evidence include acupuncture for back pain and osteoarthritis, massage therapy for muscle pain, and mindfulness practices for various pain conditions.
Beyond Pills: Lifestyle, Therapy & High-Tech Options
When it comes to taming chronic pain, medications are just one tool in a much larger toolbox. At California Pain Consultants, we believe in looking at the whole picture—your body, mind, and daily life—to find the right mix of treatments.
Movement Programs
I often hear patients say, “But doctor, it hurts when I move!” While that’s understandable, the right kind of movement can actually be your best ally against pain. Regular, appropriate exercise rarely makes things worse in the long run.
Think of movement as medicine—but like any prescription, the dosage matters. “Start low and go slow,” as Dr. Cohen often tells patients. Some of the most effective movement approaches include gentle walking, swimming or water therapy, stationary cycling, and carefully guided strength training. Many patients also find relief through tai chi and yoga.
Sleep Hygiene and Pain
Have you noticed how much worse your pain feels after a poor night’s sleep? Chronic pain treatments work better when paired with good sleep, because pain and sleep problems feed each other in a frustrating cycle.
Breaking this cycle starts with simple but powerful changes to your sleep routine: consistent bedtimes, creating a cool, dark, quiet sleep environment, and giving yourself a technology curfew. Many patients also benefit from gentle relaxation techniques before sleep.
Stress Reduction Techniques
When you’re stressed, your pain volume gets turned up. Your muscles tense, your breathing becomes shallow, and your nervous system goes on high alert—all things that can amplify pain signals.
Effective stress management doesn’t require hours of meditation. Simple practices like taking five slow, deep breaths when you feel overwhelmed, practicing gentle progressive muscle relaxation, or spending a few minutes with a guided imagery recording can make a meaningful difference.
Complementary Approaches
Chronic pain treatments like acupuncture have moved from alternative to mainstream as research confirms their benefits for conditions like back pain, osteoarthritis, and migraines. This ancient practice stimulates the body’s natural pain-relieving mechanisms.
Tai chi and yoga deserve special mention for their unique combination of gentle movement, breathing awareness, and meditation. These mind-body practices have shown particular promise for people living with fibromyalgia, arthritis, and persistent back pain.
High-Tech Pain Relief Options
When more conventional approaches haven’t provided enough relief, several advanced technologies offer new possibilities:
TENS (Transcutaneous Electrical Nerve Stimulation) devices deliver mild electrical currents through pads placed on your skin. These gentle currents interrupt pain signals and stimulate your body to release natural pain-relieving compounds.

Radiofrequency Ablation (RFA) offers longer-lasting relief for specific types of pain. This minimally invasive procedure uses precisely targeted heat to disrupt pain signals from specific nerves. It’s particularly effective for arthritis pain in the spine’s facet joints, often providing 8-12 months of significant relief.
Spinal Cord Stimulation has been a game-changer for many patients with certain types of persistent neuropathic pain. This implantable device delivers mild electrical pulses that modify pain signals before they reach your brain.
More info about spinal cord stimulation

Peripheral Nerve & Ablation Procedures
Nerve blocks serve as both diagnostic tools and treatments. These precise injections of local anesthetic can temporarily quiet overactive nerves. Common types include epidural injections for nerve inflammation along the spine, facet joint injections for spinal arthritis pain, and peripheral nerve blocks for specific nerve-related pain.
Radiofrequency Ablation (RFA) takes nerve treatment a step further. When diagnostic blocks have confirmed a specific nerve as your pain source, RFA can provide longer-lasting relief by using heat to disrupt that nerve’s pain signals.
More info about radiofrequency ablation
Cutting-Edge Chronic Pain Treatments
The field of pain management continues to evolve, with several innovative chronic pain treatments showing promise:
Scrambler Therapy takes a novel approach by using electrical stimulation to “scramble” pain signals, essentially replacing them with non-pain information.
Peripheral Nerve Stimulation (PNS) targets specific nerves rather than the spinal cord. Recent innovations include temporary systems that can be placed with minimal invasiveness.
More info about peripheral nerve stimulation
Regenerative Therapies like platelet-rich plasma (PRP) and stem cell treatments aim to promote actual healing rather than just masking symptoms.
Virtual Reality (VR) might sound like science fiction, but emerging research suggests that immersive VR experiences can significantly reduce pain perception by engaging your brain in ways that activate your internal pain control systems.
Medications & Safety Nets
While we believe in a comprehensive approach to pain management, medications remain a valuable tool when used wisely. Let’s explore your options so you can make informed choices about what might work best for your unique situation.
Non-Opioid Medications
When it comes to managing pain, we often start with safer options before considering stronger medications. NSAIDs like ibuprofen and naproxen work wonderfully for inflammatory pain, though we need to be mindful of stomach, kidney, and heart risks with long-term use.
Acetaminophen (Tylenol) offers a gentler alternative for mild to moderate pain. I often recommend it to patients who can’t tolerate NSAIDs, though we’ll make sure you stay below 3,000 mg daily to protect your liver.
For those with inflammatory pain who might be at risk for stomach problems, COX-2 inhibitors like celecoxib (Celebrex) can be a better fit.
Certain antidepressants have proven remarkably effective for nerve pain and fibromyalgia. Medications like duloxetine (Cymbalta) or amitriptyline work by adjusting pain signals in your nervous system.
Similarly, anticonvulsants like gabapentin and pregabalin have become mainstays in treating neuropathic pain. They calm overexcited nerves that might be firing pain signals inappropriately.
For pain that comes with muscle tension, muscle relaxants such as cyclobenzaprine or baclofen can provide targeted relief.
Don’t overlook topical treatments – they deliver relief right where you need it with minimal side effects. Lidocaine patches, diclofenac gel, and capsaicin creams can be surprisingly effective for localized pain.
Opioid Medications: A Cautious Approach
I believe in being straightforward about opioids. They can provide powerful pain relief, but they come with significant risks – dependence, addiction, tolerance, and various side effects. At California Pain Consultants, we approach these medications with extreme care.
“Opioids are rarely a first-line treatment for chronic pain,” explains Dr. Cohen. “They’re generally reserved for cases where other treatments have failed, the benefits clearly outweigh the risks, and close monitoring is possible.”
If we do consider opioid therapy, we’ll implement a careful framework: using the lowest effective dose for the shortest necessary time, regular monitoring including urine testing, providing naloxone for safety, and consistently reassessing whether the benefits still outweigh the risks.
Risk Mitigation Strategies
Your safety is our priority with any medication, but especially with higher-risk options. Before starting treatment, we’ll thoroughly screen for risk factors and provide clear education about what to expect. Regular check-ins help us catch any issues early.
For the latest scientific advances, you might be interested in recent research on non-opioid pain relief that shows promising alternatives on the horizon.
Chronic Pain Treatments for Patients with Substance-Use History
Having a history of substance use doesn’t mean you should suffer with untreated pain. It simply means we need to be more thoughtful in our approach to keep you safe while addressing your discomfort.
For patients receiving treatment for opioid use disorder, we work closely with your addiction treatment providers to ensure coordinated care. Buprenorphine can sometimes serve dual purposes – addressing both opioid use disorder and pain management with a better safety profile than traditional opioids.
If you’re taking naltrexone for opioid use disorder, we’ll focus on effective non-opioid strategies since naltrexone blocks opioid effects. Throughout your treatment, we’ll implement structured monitoring with clear agreements, regular follow-ups, and appropriate screening to support your recovery while managing your pain.
Creating & Adjusting Your Personalized Plan
Finding your way through chronic pain can feel like navigating without a map. At California Pain Consultants, we create personalized roadmaps that evolve with you, adjusting as we learn what works best for your unique situation.
Setting Realistic Goals
The journey to better pain management starts with knowing where you’re headed. That’s why we use the SMART framework to set goals that actually mean something in your daily life:
Specific goals give us clarity—instead of saying “I want to feel better,” we might target “I want to cook dinner without needing to sit down halfway through.”
Measurable markers help us track real progress, while keeping goals Achievable prevents the frustration of aiming too high too soon. We focus on what’s Relevant to improving your quality of life, with Time-bound checkpoints to assess how we’re doing.
“Complete pain elimination isn’t usually in the cards,” shares Dr. Cohen. “But we can almost always reduce pain to more manageable levels while helping you do more of what matters in your life.”
Tracking Your Progress
The small victories matter when managing chronic pain treatments. A simple pain diary can reveal patterns you might otherwise miss. Maybe your pain consistently spikes after certain activities or improves following specific treatments.
Beyond just pain scores, we measure what you can actually do. Being able to play with your grandchildren for 30 minutes instead of 10 is a meaningful win, even if some pain remains.
Managing Flare-Ups
Even with the best plan, pain can sometimes surge unexpectedly. Having a flare-up strategy gives you confidence to handle these difficult days.
First, learn to recognize your early warning signs. Then implement your personalized toolkit of short-term strategies—perhaps gentle stretching, applying ice, practicing deep breathing, or temporarily modifying activities. Know exactly when it’s time to reach out for additional help.
“Think of your flare plan like a fire extinguisher,” Dr. Cohen often tells patients. “You hope you won’t need it, but having it ready brings peace of mind and prevents small flares from becoming five-alarm fires.”
The Team Approach
Managing chronic pain works best when your healthcare providers function as a coordinated team rather than isolated specialists.
Your pain specialist orchestrates your overall treatment strategy, while your primary care physician manages your general health. A skilled physical therapist guides your movement program, and a psychologist or counselor helps address the emotional aspects of living with pain.
At California Pain Consultants, we serve as the central hub for this team approach. We coordinate communication between providers, ensuring everyone is working toward the same goals—your goals.
Monitoring Chronic Pain Treatments Over Time
Your pain management plan isn’t set in stone—it’s a living document that changes as your needs evolve.
When starting new chronic pain treatments, we typically check in monthly to fine-tune your approach. Once things stabilize, quarterly visits often suffice, with more frequent check-ins available during flares or treatment transitions.
Sometimes, less is more in pain management. We regularly review your medication regimen to discontinue ineffective treatments, reduce doses when possible, and simplify your routine. This “deprescribing” approach often improves outcomes by reducing side effects and interactions.
“Your pain management plan should grow with you,” Dr. Cohen emphasizes. “What works today might need adjustment tomorrow, and that’s perfectly normal. The goal is continuous improvement in your quality of life, not perfection.”
More info about Conditions & Treatments
Frequently Asked Questions about Chronic Pain Treatments
What should I ask my provider before starting any chronic pain treatments?
Stepping into pain management can feel overwhelming. That’s why having a meaningful conversation with your provider is so crucial before starting any new treatment.
I encourage my patients to come prepared with questions. Understanding your chronic pain treatments builds confidence and actually improves how well they work. Consider asking about the treatment’s mechanism—how exactly is it supposed to help? Get clear on realistic expectations, including how long before you might notice improvement.
“The most successful patients are those who become active partners in their care,” I often tell people. “Never hesitate to ask questions.”
Also important: ask about potential side effects, both common and rare ones. Discuss how you’ll monitor whether the treatment is working and what the safety checks will be. Understanding alternatives is valuable too—what other options might work for your specific condition?
Finally, have the “what if” conversation. If this approach doesn’t deliver the relief you’re hoping for, what’s the next step? Having this roadmap can ease anxiety about trying new treatments.
When are opioids considered safe for chronic pain treatments?
Opioids remain one of the most misunderstood tools in pain management. While they carry significant risks, there are situations where they may be appropriate as part of a comprehensive plan.
We typically consider opioid therapy when other chronic pain treatments have failed to provide adequate relief, and when pain significantly impacts your ability to function or enjoy life. The potential benefits need to clearly outweigh the risks.
Safety requires partnership. When I prescribe opioids, it’s only with regular face-to-face assessments, periodic urine testing, and review of prescription monitoring data. We establish clear agreements about proper use, storage, and disposal. I also ensure every patient receives a naloxone prescription as a safety net against accidental overdose.
“Opioids aren’t usually first-line treatments for chronic pain,” I explain to patients. “But for the right person, under careful supervision, they can be one piece of a comprehensive approach to improving quality of life.”
How do I know if a high-tech device is right for my chronic pain treatments?
The world of pain management has seen remarkable technological advances, from spinal cord stimulators to peripheral nerve stimulation devices. These innovations can be life-changing—but they’re not right for everyone.
Advanced interventions typically come into consideration after more conservative approaches haven’t provided adequate relief. The pain mechanism matters too; for example, neurostimulation works best for certain types of neuropathic pain.
Most devices require a psychological evaluation first. This isn’t about questioning whether your pain is “real”—it’s about ensuring you have the coping skills and support system to steer the adjustment period these technologies require.
One major advantage of many high-tech options is the ability to try before you commit. With spinal cord stimulation, for instance, you’ll undergo a temporary trial to experience the sensation and pain relief before any permanent implantation.
At California Pain Consultants, we walk you through each option step by step, ensuring you have all the information you need to make the best decision for your unique situation.
Conclusion
Living with chronic pain isn’t easy—trust me, I’ve seen how it can turn even the simplest daily tasks into mountains to climb. But with the right approach, most people can find significant relief and reclaim important parts of their lives that pain has stolen away.
At California Pain Consultants, we don’t just treat symptoms—we treat you as a whole person with unique needs, challenges, and goals. Our approach is built on years of seeing what works and what doesn’t in the real world of pain management.
Think of your journey with chronic pain treatments as creating a custom recipe. The ingredients that work for your neighbor might not work for you, and finding your perfect combination often takes some trial and error. This isn’t failure—it’s simply part of the process.
One thing I always tell my patients is to adjust their expectations. While complete pain elimination is rarely in the cards, substantial improvement is absolutely achievable for most people. Many of my patients who once thought they’d never enjoy life again have found ways to participate in family gatherings, return to modified work, or engage in hobbies they love.
Your active participation matters enormously. The patients who see the best results are typically those who view themselves as the captain of their own healthcare team, with medical providers as trusted navigators.
Pain management isn’t static. What works today might need adjustment tomorrow as your body changes, your life circumstances shift, or new treatments become available.
Our multidisciplinary team at California Pain Consultants offers comprehensive services across San Diego, Kearny Mesa, Chula Vista, Rancho Bernardo, La Mesa, and Miramar. We bring together specialists from different disciplines because we know that the most effective chronic pain treatments address physical, emotional, and lifestyle factors simultaneously.
Our goal isn’t just to reduce your pain—though that’s certainly important. It’s to help you live your fullest possible life despite pain. To help you focus less on what hurts and more on what matters.
More info about Conditions & Treatments
You don’t have to steer this journey alone. We’re here to walk alongside you, offering both cutting-edge treatments and the compassionate support you deserve. Better days are possible—and we’re committed to helping you find them.